AU - , Mamun-Al-Mahtab AU - Fazle Akbar, S TI - HBeAg negative chronic Hepatitis B: An overview PT - REVI DP - 2009 Jan 1 TA - Hepatitis B Annual PG - 131-140 VI - 6 IP - 1 4099- https://www.hepatitisbannual.org/article.asp?issn=0972-9747;year=2009;volume=6;issue=1;spage=131;epage=140;aulast=Mamun-Al-Mahtab,;type=0 4100- https://www.hepatitisbannual.org/article.asp?issn=0972-9747;year=2009;volume=6;issue=1;spage=131;epage=140;aulast=Mamun-Al-Mahtab, AB - Over 350 million people worldwide are infected with hepatitis B virus (HBV), and patients with HBeAg-negative chronic hepatitis B constitute a major proportion of this population. Mutant varieties of HBV resulting from mutations in the precore or core promoter region of the viral genome give rise to HBeAg-negative CHB, and these cases must be differentiated from the inactive carrier state. These patients with HBeAg-negative CHB must be managed judiciously and in certain situations kept under close follow-up instead of rushing to treatment. However, this does not mean advocating adoption of a too conservative approach, allowing many to proceed to irreversible and progressive liver disease. This article provides an overview of the management of HBeAg-negative chronic hepatitis B.