Hepatitis B Annual

: 2010  |  Volume : 7  |  Issue : 1  |  Page : 16--27

Goals of therapy in patients with CHB

Ajay Duseja 
 Department of Hepatology, PGIMER, Chandigarh, India

Correspondence Address:
Ajay Duseja
Department of Hepatology, PGIMER, Chandigarh - 160 012

Despite the development of a number of antiviral agents for treatment of Chronic Hepatitis B, the treatment of chronic hepatitis B continues to be a challenge for physicians due to the high burden of the disease and the limited efficacy of available therapy. The primary goal of treatment is to eliminate or suppress HBV in order to decrease pathogenicity and infectivity, and reduce hepatic necroinflammation. Clinically, the short-term goal of treatment is to reduce hepatic activity, to prevent the development of hepatic decompensation, to ensure loss of HBeAg (with seroconversion to anti-HBe) and/or HBV-DNA with alanine aminotransferase (ALT) normalization at the end or 6-12 months after the end of treatment. The long-term goals are eradication of infection, prevent progression to cirrhosis, prevent development of HCC, and ultimately prolong survival. This review discusses the goals of therapy in patients with chronic hepatitis B.

How to cite this article:
Duseja A. Goals of therapy in patients with CHB.Hep B Annual 2010;7:16-27

How to cite this URL:
Duseja A. Goals of therapy in patients with CHB. Hep B Annual [serial online] 2010 [cited 2022 Dec 9 ];7:16-27
Available from: https://www.hepatitisbannual.org/article.asp?issn=0972-9747;year=2010;volume=7;issue=1;spage=16;epage=27;aulast=Duseja;type=0